Antonov-225, the world's biggest aircraft, is due to touchdown at East Midlands airport on Thursday evening.
The Ukrainian-built plane will land at around 6pm and stay overnight before taking off again at around 10am on Friday.
It is powered by six engines and is the longest and heaviest plane ever built with a maximum take-off weight of 640 tonnes.
It also has the largest wingspan of any aircraft currently in service.
A 189-tonne generator for a gas power plant in Armenia was transported on an Antonov-225 in 2009, and in June 2010 it carried the world's longest piece of air cargo when it flew two new 42-metre test wind turbine blades from China to Denmark.
The craft has only visited East Midlands Airport six times.
