Shares in the new company created by the merger of Alliance Boots and US drugstore group Walgreens will begin trading in America today.
The move will see Boots, which employs about 8,000 people in Nottingham, become American-owned for the first time since 1920.
A total of 97 per cent of Walgreen shareholders voted to approve the merger on Monday.
The new company will be named Walgreens Boots Alliance and will be headquartered in Deerfield, near Chicago.
Boots UK will continue to be run from Nottingham.
Walgreens and Alliance Boots will become wholly-owned subsidiaries of Walgreens Boots Alliance.
Together, Walgreens Boots Alliance spans more than 25 countries, with over 12,800 stores, more than 370,000 employees and more than 340 pharmaceutical distribution centers serving in excess of 180,000 pharmacies and other points of care.
The prospect of a merger was agreed in 2012 when Walgreens bought a 45 per cent interest in Alliance Boots.
The Post reported in August that Walgreens intended to buy the rest of the Nottingham-based company.
Earlier this month, it was announced that Alex Gourlay, former chief executive of Alliance Boots health and beauty division, including Boots 2,500 stores in the UK, was to become president of Walgreens.
He will move his job as president of customer experience and daily living, which he took up little over a year ago, moving from the UK to Deerfield.
Greg Wasson, president and chief executive of Walgreens, who led the merger talks with Alliance Boots, is to step down after 35 years.
Stefano Pessina, who created Alliance Boots by merging Alliance Unichem and Boots and later taking it off the London Stock Exchange, will own about 20 per cent of the new business valued in the region of $13billion (£8.4 billion).
He is expected to become interim chief executive but return to a strategic roll retaining his seat on the board.
Mr Wasson said: "The creation of Walgreens Boots Alliance is a crucial milestone for both Walgreens and Alliance Boots, combining iconic brands, complementary geographic footprints, shared values and a heritage of trusted healthcare services through pharmaceutical wholesaling and community pharmacy care, each dating back more than 100 years.
"The combination instantly establishes a groundbreaking and game-changing new company that will help people across the world lead healthier and happier lives as we advance our industry and the delivery of retail health, wellbeing and beauty products and services worldwide."
Mr Pessina said, "The combined strength, scale and expertise of Walgreens Boots Alliance creates a unique and unparalleled global leader. We have forged a worldwide healthcare champion, which will provide innovative ways to address global health and wellbeing challenges by helping to shape retail pharmacy, healthcare and pharmaceutical wholesale markets around the world. Becoming global gives us the ability to generate significant and sustainable benefits for local markets and all stakeholders, from consumers and patients, to pharmacists, suppliers, business partners and, of course, our employees."
Walgreens Boots Alliance Chairman Jim Skinner said, "On behalf of the board, I would like to express our gratitude to Greg for his outstanding vision, work and commitment towards creating this new company. I am looking forward to working closely with Stefano and the senior management team of Walgreens Boots Alliance as we start this exciting mission of bringing better health and wellbeing to the world."
Walgreens and Alliance Boots announced their two-step strategic transaction in June 2012. They completed Step one in August 2012, when Walgreens invested around $4.0 billion in cash and 83.4 million shares of its common stock in exchange for a 45 percent equity ownership stake in Alliance Boots. With the completion of Step two, Walgreens has acquired the remaining 55 percent of Alliance Boots in exchange for around $5.3 billion in cash and 144.3 million shares of stock.
The completion of this strategic transaction marks a historic milestone for both companies with roots going back more than a century.
Walgreens has grown from a single corner in Chicago in 1901, to the best corners in America.
Boots was founded by John Boot in 1849. His son, Jesse assumed sole control of the business in 1877. The company was briefly owned by a US company from 1920 to 1933.
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